1.基础信息
姓名：付蕾 职称：研究员
办公室：沧海校区致信楼N602 导师类别：硕导
邮箱：leifu@szu.edu.cn 办公室电话：18811570587
2. 个人简介
付蕾，深圳大学电子信息工程学院硕士生导师，深圳大学附属华南医院研究员，现任深圳大学附属华南医院医学人工智能所常务副所长。2021年博士毕业于北京师范大学方维海院士团队；2019-2020年受国家留学基金委资助公派留学美国Boston University，导师Qiang Cui；2016年于美国University of Wisconsin-Madison进行访问学习，导师Frank A. Weinhold。博士后阶段于中国科学院广州生物医药与健康研究院和深圳市罗湖区人民医院和浙江大学从事研究工作。在Journal of Clinical Investigation, Nature Communications, Journal of Medicinal Chemistry, Briefings in Bioinformatics, Journal of Physical Chemistry Letters, Biophysical Journal等国际学术期刊发表论文20余篇。
3. 主要研究方向
主要研究方向包括生命科学、医学、药学、材料等多学科交叉领域的AI4Science工作，结合高性能计算和人工智能在肿瘤免疫领域的分子机理解析、蛋白质互作、生物大分子机制、抗原肽/抗体优化设计、人工智能辅助的药物的理性设计及其在疾病防治中的应用等。
研究方向
- 人工智能辅助药物理性设计（AIDD）
- 人工智能辅助的蛋白质设计和生物大分子机制
- 基于物理和数据驱动的AI模型
- 肿瘤免疫领域的抗原抗体设计
- 抗菌肽的杀菌机制研究
4. 招生方向和要求
新一代电子信息技术
研究方向:人工智能辅助药物设计/生物医学大模型和智能体/计算生物学
招生要求：
专业课基础扎实，业务能力强，精通一门编程语言(Python，C/C++，Fortran)，有较好的英语读写能力，对人工智能，计算生物学及其交叉研究有浓厚兴趣，有良好的动手实践能力与团队合作精神，学习积极努力，认真踏实。
5. 主持科研项目
1. 深圳市医学研究院，2025年度深圳市医学研究专项“揭榜挂帅”项目，E250200620，人工智能赋能的复杂疾病系统解析及干预策略研究，2026-01至2029-12，1000万元，在研，项目骨干。
2. 深圳市科技创新局，2025年度重点产业研发计划，ZDCY20250901110900001，面向端侧医疗大模型的部署优化与国产芯片适配技术研发，2026-01至2028-12，500万元，在研，参与。
3. 深圳市科技创新局，2025年应用研究类，深圳市医学数字孪生关键技术重点实验室，2025-12至2028-12，500万元，在研，骨干成员。
4. 重庆市科技局, 2025年度重庆市自然科学基金创新发展联合基金（重点项目）, CSTB2025NSCQLZX0079, 生成式AI结合多生物模型验证的动态迭代小分子药物预测系统的开发, 2026-01 至 2027-12，25万元, 在研, 项目骨干。
5. 深圳市科技研发基金，深圳市优秀科技创新人才培养，RCJC20200714114557005，膀胱癌分子机理研究及早筛与诊疗体系构建，2021-04-01至2026-04-01，450万元，在研，参与。
6. 上海人工智能实验室, 科研项目, P22KN00272, “计算+”智能化免疫抗原肽的设计与应用, 2022-01至 2023-12, 500万元，结题，参与。
7. 国家自然科学基金委员会, 面上项目, 21973004, 基于严格优化方法的生物分子粗粒化力场开发及应用, 2020-01 至 2023-12, 65万元, 结题, 参与。
6. 代表性成果
[1]Zifan Ye, Xia Wang, Zhouye Xu, Taizhong Wang, Juan Wang, Shuangyu Li, Xiangjin Kong, Jingjing Zhang, Xudong Jiao, Lei Fu*, Yipeng Wang*. CATHPb1, a broad-spectrum and multi-target antibiotic adjuvant to combat drug-resistant bacterial infections. Science China-Life Science.2026.IF=9.5
[2]Lei Fu, Kevin Chun Chan, Qinglu Zhong, Damiano Buratto, Song Wu*, Ruhong Zhou* In Silico Optimization of GAD65114-122 Autoantigen for Potential Type 1 Diabetes Antigen-specific Immunotherapy. The Journal of Physical Chemistry B. 2025, 129, 12799−12810.
[3]Qinglu Zhong, Kevin C. Chan, Lei Fu, Ruhong Zhou*. A free energy perturbation-assisted machine learningstrategy for mimotope screening in neoantigen-basedvaccine design. Briefings in Bioinformatics, 2025, 26(4),bbaf254.
[4] Zifan Ye,¶ Lei Fu,¶ Shuangyu Li, Ziying Chen, Jianhong Ouyang, Lianghui Gao,*, Yipeng Wang* Synergistic antibacterial effects between antimicrobial peptides and cationic peptides are a widespread immune defense strategy in animals. Nature Communications. 2024, 15:7319. (contributed equally as first author) IF=17.69
[5] l Qianqian Zhuang,¶ Fengfeng Guo,¶ Lei Fu,¶ Tilo Kunath, Ruhong Zhou*, Ping Liang*, Zhong Liu*, Qingfeng Yan*. 1-Deoxynojirimycin as a potential mitochondrial rescue agent for maternally inherited hypertrophic cardiomyopathy. Journal of Clinical Investigation, 2023, 133:e164660.(contributed equally as first author)IF=19.456
[6] l Jianqiang Mu,¶ Chenyang Xue,¶ Lei Fu,¶ Mengqi Wu, Xinmeng Chen,Kun Liu, Ruiqian Bu1, Ying Huang, Baisheng Yang, Jianming Han, Qianru Jiang, Zongjun Yu, Chun Chan, Ruhong Zhou, Ancheng Huang, Yong Wang, Zhongmin Liu*. Conformational cycle of human polyamine transporter ATP13A2. Nature Communications. 2023, 14:1978.(contributed equally as first author) IF=17.69
[7] lXiangyuan Li,¶ Lei Fu,¶ Shan Zhang, Yipeng Wang, Lianghui Gao*. How Alligator Immune Peptides Kill Gram-Negative Bacteria: A Lipid-Scrambling, Squeezing, and Extracting Mechanism Revealed by Theoretical Simulations. International Journal of Molecular Sciences. 2023, 24:10962. (contributed equally as first author)
[8] l Lei Fu, Xiangyuan Li, ShanZhang, Yi Dong, Weihai Fang, and Lianghui Gao*. Polymyxins Induce Lipid Scrambling and Disrupt the Homeostasis of Gram-Negative Bacteria Membrane. Biophysical J. 2022, 121:1-13.
[9] lMinghui Zhang¶,Jianhong Ouyang¶,Lei Fu¶, Fen Zhang, Yan Wang, Xuanjin Luo, Dengdeng Zhang, Lianghui Gao,*Yipeng Wang*. Hydrophobicity determines the antimicrobial rate of amphipathicα-helical antimicrobial peptides. Journal of Medicinal Chemistry. 2022, 65:14701-14720. (contributed equally as first author) IF=8.42
[10] l Lei Fu, Mingwei Wan, ShanZhang, Lianghui Gao,* and Weihai Fang. Polymyxin B Loosens Lipopolysaccharide Bilayer but Stiffens Phospholipid Bilayer. Biophysical J. 2020, 118:1-13.
[11] Linlin Li¶, Rongxi Wang¶, Li He¶, Hua Guo, Lei Fu, Guochang Wang, Jiarou Wang, Ziying Chen, Xingtong Peng, Xinyu Lu, Huimin Sui, Yuanyuan Jiang, Jie Zang*, Lianghui Gao*, and Zhaohui Zhu*. Evaluation of Angiotensin-Converting Enzyme 2 Expression In Vivo with Novel 68Ga-Labeled Peptides Originated from the Coronavirus Receptor-Binding Domain. ACS Pharmacology & Translational Science 2024, 7, 3119−3130.
[12] Xiangyuan Li, Lei Fu, Shan Zhang, Yi Dong, and Lianghui Gao*. Relationship between Protein-Induced Membrane Curvature and Membrane Thermal Undulation. The Journal of Physical Chemistry B. 2024, 128:515-525.
[13] Junjie Song, Lei Fu, Hong Li, Yue Su, Qiong Wang, Guiqiu Zhang,* and Jin Wang*. Equivalent and Complement of the ω-Bonding Model and Charge-Shift Bonding Model: A Natural Bond Orbital/Natural Resonance Theory/Atoms in Molecules Investigation via Cu/Ag/Au Bonding in BMX (B = H2O, H2S, NH3, and PH3; M = Cu, Ag, and Au; and X = F, Cl, Br, and I). The Journal of Physical Chemistry Letters.2023, 14:5226-5233.
[14] Yi Dong, Lei Fu, Junjie Song, Shan Zhang, Xiangyuan Li, Weihai Fang, Qiang Cui,* and Lianghui Gao*. Thermodynamic Driving Forces for Divalent Cations Binding to Zwitterionic Phospholipid Membranes. The Journal of Physical Chemistry Letters.2022, 13:11237−11244.
[15] Xuanjin Luo,¶ Jianhong Ouyang,¶ Yan Wang,¶ Minghui Zhang,Lei Fu, Ning Xiao, Lianghui Gao, Jiang Zhou*, Yipeng Wang*The first anionic cathelicidin lacking direct antimicrobial activity but with potent anti-inflammatory and wound healing activities from salamander, Tylototriton kweichowensis.Biochimie. 2021, 191:37.
[16] Shan Zhang, Ming Ma, Zhuang Shao, Jincheng Zhang, Lei Fu, Xiangyuan Li, Weihai Fang, and Lianghui Gao*. Structure and Formation Mechanism of Antimicrobial Peptides Temporin B- and L-Induced Tubular Membrane Protrusion. International journal of Molecular Sciences.2021, 22:11015.
[17] Guiqiu Zhang,*Yue Su, Xiaoran Zou, Lei Fu, Junjie Song, Dezhan Chen and Chuanzhi Sun*. Charge-Shift Bonding in Xenon Hydrides: An NBO/NRT Investigation on HXeY···HX (Y = Cl, Br, I; X = OH,Cl, Br, I, CCH, CN) via H-Xe Blue-Shift Phenomena.Frontiers in Chemistry. 2020, 8:277.
[18] ShanZhang, Lei Fu, Mingwei Wan, Junjie Song, Lianghui Gao,* and Weihai Fang. Peripheral Antimicrobial Peptide Gomesin Induces Membrane Protrusion, Folding, and Laceration. Langmuir.2019, 35:13233-13242.
[19] Yu Shi, Mingwei Wan, Lei Fu, Shan Zhang, Shiyuan Wang, Lianghui Gao,* and Weihai Fang. Peptide-Lipid Interaction Sites Affect Vesicles’ Responses to Antimicrobial Peptides. Biophysical Journal.2018, 115:1518-1529.
[20] Guiqiu Zhang,* Junjie Song, Lei Fu, Kongshuang Tang, Yue Su and Dezhan Chen. Understanding and modulating the high-energy properties of noble-gas hydrides from their long-bonding:an NBO/NRT investigation on HNgCO+/CS+/OSi+ and HNgCN/NC (Ng = He, Ar, Kr, Xe, Rn) molecules. Physical Chemistry Chemical Physics. 2018, 20:10231-10239.
[21] Guiqiu Zhang,* Lei Fu, Hong Li, XuchanFan and Dezhan Chen, Insight into the Bonding Mechanism and the Bonding Covalency in Noble Gas-Noble Metal Halides: An NBO/NRT Investigation. The Journal of Physical Chemistry A. 2017, 121:5183–5189.
[22] Guiqiu Zhang,*HuiWang, Huanjing Yue, Hong Li, Shengnan Zhang, and Lei Fu. Ligand effects due to resonance character in LAuCCH−(L=F, Cl,Br, I, CCH) complexes: an NBO/NRT analysis. Journal of Molecular Modeling. 2015, 21: 159.
7. 学术任职
1. 中国电子学会智慧医疗分会委员
2. 《Interdisciplinary Sciences: Computational Life Sciences》杂志，JCRQ1, 青年编委
3. 《Artificial Intelligence and Proactive Health》杂志，青年编委
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