1.基本信息
姓名：马婧 职称：副研究员
导师类别：硕导 邮箱：maj88@szu.edu.cn
办公室地址：沧海校区致信楼N602办公室 办公室电话：0755-21583945
2.个人简介
马婧，博士，副研究员，硕士生导师，药物临床试验机构办公室主任。2019年博士毕业于香港大学，博士导师为黄思齐教授。主持国自然面上项目、青年基金、深圳市优秀科技创新人才培养优青项目、深圳市医学研究专项资金等多项科研项目，研究经费600余万元。近年来以第一作者和通讯作者身份在Adv Mater.，Adv Func Mater.，Cell Rep.，Biomaterials，Biosens Bioelectron.，Mol. Ther.，ACS Appl Mater Interfaces.等高水平学术期刊发表SCI论文10余篇。授权发明专利7项。
3.主要研究方向
1. 医学大语言模型与智能体
聚焦于构建面向医疗健康领域的专用大语言模型与智能决策系统，开展医学文本语义理解、临床知识问答、病历自动生成与辅助诊断等研究。通过融合医学知识图谱与深度学习技术，开发具备可解释性与安全性的医疗智能体，支持临床决策、患者管理与科研辅助等多场景应用。
2. 生物分子相互作用模拟与预测
结合计算生物学与人工智能方法，开展蛋白质-蛋白质、蛋白质-小分子等生物分子相互作用的建模与预测研究。利用图神经网络、分子对接模拟与结构生物学数据，探索疾病相关分子机制，辅助靶点识别与药物筛选，推动精准医学发展。
3. 医学图像处理与分析
围绕医学影像开展智能处理与分析研究，包括图像分割、特征提取、病灶检测与分类等任务。结合深度学习与多模态数据融合技术，提升影像诊断的自动化与精准度，支持临床辅助诊断与治疗评估。
4.代表性成果等
1. Ma J, To SKY, Zhang X, Zhao W, Zhang P*, Wong AST*. Emerging perspectives on metabolic reprogramming in the microenvironment of ovarian cancer metastasis. BBA - Reviews on Cancer. 2026, 1881, 189554.
2. Ji C#, Ma J#, Wang H, Liu S, Shi Y, Zhang P*, Wang Z*. Efficient visible light activated afterglow through stabilizing excited dimers via a melt-injection reaction for multiple applications. Adv Optil Mater. 2025, e02328.
3. Ma J#, Zhang XY#, Xiong J#, Zhang C, Zhu S, Cao W, Wei J*, Zhang P*. Design of a quinoxalinone-based AIE probe for the detection of ROS in in vitro and in vivo sepsis models. Biomater. Sci. 2025, 13(12):3298-3306.
4. Ma J#, To SKY#, Fung KSW#, Wang K#, Zhang J, Ngan AHW, Yung S, Chan TM, Wong CCL, Ip PPC, Peng L, Guo HY, Chan CB*, Wong AST*. P-cadherin mechanoactivates tumor-mesothelium metabolic coupling to promote ovarian cancer metastasis. Cell Rep. 2025, 44(1):115096.
5. Fan L#, Zhang P#, Gan Y#, Li L, Wang L, Wang M, Liu X, Ma J*, Liu B*, Shi L*.A Molecular-Targeting Photosensitizer to Inhibit DNA Damage Repair System and Induce cGAS-STING Pathway Activation for Photo-Immunotherapy of Ovarian Cancer, Adv. Func. Mater. 2025, 35(6): 2415087.
6. Zhang P#, Li Z#, Cao W, Tang J, Xia Y, Peng L*, Ma J*.A PD-L1 antibody-conjugated PAMAM dendrimer nanosystem for simultaneously inhibiting glycolysis and promoting immune response in fighting breast cancer. Adv Mater. 2023, 35(41):e2305215 (Frontispiece)
7. Kuang H#, Ma J#, Chi X, Fu Q, Zhu Q, Cao W, Zhang P*, Xie X*. Integrated osteoinductive factors-exosome@microRNA-26a hydrogel Enhances bone regeneration. ACS Appl Mater Interfaces. 2023, 15(19):22805-22816.
8. Ma J, Wang S, Wang T, Ma J*, Wang Z*. Ratiometric fluorescence assay for pyrophosphate based on sulfur nanodots decorated metal organic frameworks. Chemistry. 2023, 29(35):e202300366.
9. Cui Y, Zhang Z, Zhang Y, Li C, Sang F, Song X, Cao W, Zhang P, Ma J. Effectiveness of yupingfeng granules in the treatment of chronic urticaria: a systematic review and meta-analysis. J. Herb. Med. 2023, 42, 100817.
10. Zhang P, Kuang H, Xu Y, Shi L*, Cao W, Zhu K*, Xu L, Ma J*. Rational design of a high-performance quinoxalinone-based AIE photosensitizer for image-guided photodynamic therapy. ACS Appl Mater Interfaces 2020, 12, 42551-42557.
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